M protein mediates streptococcal adhesion to HEp-2 cells

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M protein mediates streptococcal adhesion to HEp-2 cells.

Streptococcus pyogenes adheres to human epithelial cells in vitro and in vivo. To identify adhesins, cell wall components were extracted from S. pyogenes M6 with alkali or by treatment with mutanolysin and lysozyme. HEp-2 cells were incubated with extracts of S. pyogenes M6 and then analyzed by Western blot (immunoblot) assays, using antibodies to S. pyogenes. Only one streptococcal component (...

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M proteins that define the serotypes of group A streptococci are powerful blastogens for human T lymphocytes. The mechanism by which they activate T cells was investigated and compared with the conventional T cell mitogen phytohemagglutinin, and the known superantigen staphylococcal enterotoxin B. Although major histocompatibility complex (MHC) class II molecules are required for presentation, ...

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association between efficient adhesion to hep-2 cells and severity of gastritis in helicobacter pylori strains isolated from children

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ژورنال

عنوان ژورنال: Infection and Immunity

سال: 1994

ISSN: 0019-9567,1098-5522

DOI: 10.1128/iai.62.2.442-448.1994